alexa A Sub-Chronic Exposure Study of Arsenic on Hematological Parameters, Liver Enzyme Activities, Histological Studies and Accumulation Pattern of Arsenic in Organs of Wistar Albino Rats

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A Sub-Chronic Exposure Study of Arsenic on Hematological Parameters, Liver Enzyme Activities, Histological Studies and Accumulation Pattern of Arsenic in Organs of Wistar Albino Rats

The aim of this study was to determine the hematological and biochemical changes occurred in the blood of arsenic-exposed Wistar albino rats during 90 days sodium-arsenite exposure study, and additionally to investigate the histological injury in the organs (liver, kidney, spleen and heart) of Wistar rats along with identifying the accumulation pattern of arsenic in those organs. Wistar rats received the following treatments: (1) distilled water; (2) arsenic (10 ppm); (3) arsenic (30 ppm) (4) arsenic (50 ppm). We found anemia, immunosuppression as well as significant increase in liver enzyme activity in the blood of arsenic intoxicated rats. Moreover, this toxic metalloid produced marked necrosis in liver and kidney of rats, whereas in heart mild muscle necrosis was observed. In case of spleen, enlarged white pulp was seen with marked hemorrhage and necrosis. Besides, we also have found that liver and spleen accrued more arsenic than kidney and heart. So, for better understanding of the toxic effects of arsenic the findings of our study in animal model might become useful which will also aid to develop effective drug against arsenic mediated toxic effects on human health.

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