alexa A Fast Analytic Simulation of Stochastic Mutation and its Application to Modeling Cancer Drug Resistance

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A Fast Analytic Simulation of Stochastic Mutation and its Application to Modeling Cancer Drug Resistance

Random “Darwinian” mutation is a primary mechanism by which cancer and pathogens develop resistance to drugs, and this process has been mathematically modeled extensively. Analytic models employ simple equations and allow for very fast computation, but do not accurately predict mutation times or survival probabilities of resistant populations. Stochastic models provide a distribution of probable outcomes but involve more complex mathematics.

 
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