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Chronic hepatitis C infection (CHC) is acknowledged as a major health problem all over the world. The World Health Organization estimates that 3-4 million individuals are infected each year worldwide, with a global 170 million chronic HCV carriers at risk of developing liver cirrhosis and/or liver cancer. The most experienced treatment for chronic hepatitis C is pegylated interferon (PEGINF) and ribavirin (RBV) combination therapy. A variety of conditions ranging from endocrinopathies to different skin diseases have been described in only HCV infections and/or associated with IFN based therapy.
