alexa Stochastic Mutation and its Application

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Stochastic Mutation and its Application

We model the mutation event from a sensitive “wild-type” cancer cell population S to a resistant “mutant” cancer cell population R under the following assumptions: cell mutation, division, and death are random Markov processes; the sensitive population is known from patient data; all cells are assumed to be cancer “stem” cells with the same probabilities of mutation, natural death, and division; and all cells divide simultaneously at the end of the cell cycle model shown...Read more...

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