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A search of the literature shows that overall interest in gene therapy, as indicated by publication numbers, has been on a slow decline for over a decade, since the year 2000. In spite of this the stunning potential of gene therapy to revolutionize modern medicine remains unfulfilled. ÃÂe bottleneck of NIH funding for basic research and lack of means to enter into the clinical trials pipeline (toxicology and Phase I-III clinical trials) strongly limits advancements in gene therapy-based medical breakthroughs. Within the declining general field, publications on adeno-associated virus (AAV) - and lentivirus-based continue to rise and offer some hope for the future.
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