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Tumor tissues are just like normal tissues; require nutrients, oxygen and the ability to evacuate waste products and CO2 , the process of angiogenesis or (tumor-associated vascularization) addresses these needs to tumor tissues. The process of angiogenesis in tumors is continuously activated; triggering the normal vasculature to sprout out new vessels to sustain the tumor growth. The resulting new blood vessels “feed” growing tumors with oxygen and nutrients, allowing the cancer cells to invade nearby tissue and metastasize around, forming new colonies of cancer cells. This process is governed by several inducing and opposing factors, some of these factors are signaling proteins, which bind to the cell-surface receptors on the vascular endothelial cells causing their stimulation or inhibition. Vascular Endothelial Growth Factor-A or for short “VEGF-A” is a well-known angiogenic inducer.
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