Mature cells can be rejuvenated to become pluripotent- the discovery for which Dr. Yamanaka and Dr. Gurdon won the 2012 Nobel Prize in medicine and physiology. A few scientists can be recognised in this very special way. On the other hand, many other great scientists contributed to this field so they will not be snubbed here. Just to introduce a few names, Dr. James Thomson, who with Yamanaka won the King Faisal International Prize for Medicine in 2011 jointly for their work on stem cell therapy, is the pioneer to first isolate human embryonic stem (ES) cells in the lab back in 1998 and also showed that mature human body cells could be reversed into stem cells in Science in 2007.Here is a concise historical review and some perspectives on the spotlighted nuclear transplantation (cloning) and induced pluripotent stem cells (iPSC). Besides, we propose that iPSC may be hypothetically considered one exceptional case among “cancerous” cells. The argument between stochastic and elite model of iPSC is briefly discussed.