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Currently, the discovery of Compounds induced Pluripotent Stem Cells (CiPSCs) and the Stimulus-Triggered Acquisition of Pluripotency (STAP) cells are rocking the field of stem cells. In 1981, the first embryonic stem cells (ESCs) were first derived from mouse embryos by two groups respectively. In 1998, a breakthrough occurred when Thomson group first developed a technique to isolate and grow human ESCs in cell culture. The finding of ESCs, especially the human ESCs, brought the hope for the regeneration medicine. However, because of the ethic issues and potential xenograft rejection problems of human ESCs, it is very hard for the derivatives of human ESCs to go directly towards clinical application.
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