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Micronucleus (MN) is a small additional nucleus and is easily identified by light microscopy. Micronucleus scoring could be used as a bio-marker to identify different pre-neoplastic conditions much earlier than the presentation of clinical features and might specifically be exploited in the screening of high-risk population for a specific cancer and it has clearly revealed that the level of baseline chromosome damage in untreated cancer patients is much more than in cancer-free controls. As a result, the prevalence of MN in epithelial cells has been considered a potential tissue-specific indicator of cancer risk.