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Mammalian ovaries comprise follicles containing maturing oocytes, thecal cells, and interstitial cells. Control of folliculogenesis involves interactions between the pituitary gonadotrophins, folliclestimulating hormone (FSH), and luteinizing hormone (LH), and intraovarian factors such as steroids, cytokines, and growth factors. The latter stage of folliculogenesis is strictly controlled by FSH and LH [1,2], both of which are preferentially produced in females. Therefore, it is possible that the development of mammalian ovaries placed in a male hormonal environment would be suppressed because of the presence of only small amounts of female-specific hormones and large quantities of male androgens.
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