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The D-neuron in the rat central nervous system (CNS) was described by Jaegeret al. in 1983. Initially, they defined as “the nonmonoaminergic aromatic L-amino acid decarboxylase (AADC)- containing cell”, and called the “D-cell”. AADC is an equivalent enzyme to dopa decarboxylase (DDC). The D-cell contains AADC but not dopaminergic nor serotonergic. Then, it is natural that the D-cell is thought to produce the trace amine (TA), such as β-phenylethylamine (PEA), tyramine, tryptamine and octopamine. AADC is the ratelimiting enzyme for TA synthesis. However, it is confusing that these TAs are also “monoamines”, as each TA has one amino residue. D-cells which Jaeger et al. reported were proved to be neurons by electromicroscopic observation, and they are also called D-neurons...Read more
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