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Force-Velocity Relation: Its Implications about Molecular Mechanism of Muscle Contraction

In 1938, Hill described the relation between force (P=load) and initial velocity of shortening (V) in contracting whole frog muscles as part of rectangular hyperbola: (P + a) V=b (Po – P), where Po is the maximum isometric force and a, b are constants. This equation indicates that muscle can regulate its energy output depending to the amount of load imposed on it. View more....


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