Blood-brain barrier (BBB) damage as one of the underlying mechanisms of CM, with leaky BBB allowing toxic compounds to enter the brain and cause neurological dysfunction. The BBB is constituted of cerebral vascular endothelial cells, which do not form a rigid structure, but rather a dynamic interface with a range of physical, biochemical and immune properties and functions, built from effective inter-cellular junctions and cell-matrix adhesion molecules, enzymes, and trans-endothelial transport systems.
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Last date updated on January, 2021