Bone marrow stromal cells (BMSCs) are a critical cellular element of the marrow microenvironment and support the production of blood cells from the bone cavity in adults. Dysfunction of BMSCs has been directly associated with the promotion of hematological diseases such as multiple myeloma and myelodysplastic syndromes. Clinically, these cells have been increasingly explored in therapeutic trials for regenerative medicine and immune-mediated diseases based on their pleiotropic functions, many of which remain poorly understood. The ontogeny of BMSCs, although relatively unexplored, may provide insight into the specialized functions of these cells. However, the developmental precursor of BMSCs has been difficult to identify because BMSCs have no distinguishing features to track in vivo.
There is evidence that sites of developmental hematopoiesis, including the placenta, aorta-gonad-mesonephros, and fetal liver, are also populated by embryonic BMSCs. However, once expanded in culture from human bone marrow samples these isolated fibroblastoid cells are typically negative for the pan-hematopoietic marker, CD45, and a progenitor cell marker, CD34. Conflicting reports exist on the variable expression of CD34 in mouse preparations.
Biju Parekkadan, Evidence of a Hematopoietic Origin of Human Bone Marrow Stromal Cells
Last date updated on April, 2021