alexa Bone Marrow Impact Factor|OMICS International|Journal Of Bone Marrow Research

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Bone Marrow Impact Factor

Mesenchymal stem cells (MSCs) self-replicate and differentiate into a variety of cell types such as osteoblasts, chondrocytes, adipocytes, and smooth muscle cells. These capacities have made MSCs useful in studies of bone and cartilage regeneration. One of the sources of human MSCs (hMSCs) is adult bone marrow, although they occur at a rate of one per one-hundred-thousand nucleated cells, and the available volume of bone marrow is limited. To secure the numbers of hMSCs required for tissue regeneration, the cell must be expanded ex vivo. Although hMSCs are stable ex vivo, it is possible that they undergo transformation to an unlimited proliferation phenotype during expansion. Previous studies have demonstrated that Ewing’s sarcoma is derived from MSCs. Ewing’s sarcoma is a malignancy that primarily affects children and young adults, with a peak incidence between the ages of 14 and 20 years. It arises mainly in bone and less commonly in soft tissues. The t(11;22)(q24;q12) chromosomal translocation generating EWS-FLI-1 fusion gene is found in 85% of cases. EWS-FLI-1 knockdown inhibits cell proliferation in Ewing’s sarcoma cells. Thus, EWS-FLI-1 expression is believed to play a key role in Ewing’s sarcoma development. However, EWS-FLI-1 expression does not transform normal murine and human fibroblasts, suggesting EWS-FLI-1 promotes malignant transformation in selective cells. Rumi Sawada, Cyclin D2 Promotes the Proliferation of Human Mesenchymal Stem Cells Impact Factor is a population statistic that reflects how many citations of a journal’s papers published over a two-year period receive during the subsequent year. “The annual Journal Citation Reports impact factor is a ratio between citations and recent citable items published: a journal’s impact factor is calculated by dividing the number of current year citations to the source items published in that journal during the previous two years.Medical Journals provide a podium for unresolved research around the globe in the field of medicine. Medical journals contribute for the advancement and development of the scientific discoveries. Medical journals publish papers which provide information on diagnosis, treatment & prevention of various diseases.
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Last date updated on July, 2014

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