|Infusion of bone marrow stem cells in mice have reduced heart inflammation and fibrosis of the gain area in the healthy heart, after six months of treatment. In addition, another study analyzed the direct administration of mesenchymal stem cells from bone marrow in the left ventricular wall in co-culture with skeletal myoblasts for 14 days, showing improvement in LEVF 23% to 34% of the heart, contraction of volume reduction systolic and diastolic blood pressure and the presence of myogenesis and angiogenesis after treatment. In another preclinical model of left ventricular dysfunction after myocardial infarction in pigs subjected to infusion of bone marrow stem cells resulted in the formation of new cardiac tissue, with a relative reduction of infarct size and hemodynamic improvement. The evidence of efficacy without obvious safety concerns in 8 week followup motivated studies in human patients post- myocardial infarction and chronic ischemic cardiomyopathy.
Idiberto JosÃ© Zotarelli Filho, Cardiomyopathy and Cell Therapy: Ejection Fraction Improvement and Cardiac Muscle Mass Increasing, after a Year of Bone Marrow Stem Cells Transplantation, by Magnetic Resonance Image