Glycine Encephalopathy

Non-ketotic hyperglycinaemia was first described by Gerritsen et al. in 1965 . The defect in the glycine cleavage system results in an excessive accumulation of glycine in all tissues, but particularly in the CNS. Classification is based on the age at initial presentation and clinical outcome. This includes neonatal severe, neonatal mild, infantile mild, and infantile severe. Non-ketotic hyperglycinaemia was first described by Gerritsen et al. in 1965 . The defect in the glycine cleavage system results in an excessive accumulation of glycine in all tissues, but particularly in the CNS. Classification is based on the age at initial presentation and clinical outcome. This includes neonatal severe, neonatal mild, infantile mild, and infantile severe. Non-ketotic hyperglycinaemia was first described by Gerritsen et al. in 1965 The defect in the glycine cleavage system results in an excessive accumulation of glycine in all tissues, but particularly in the CNS. Classification is based on the age at initial presentation and clinical outcome. This includes neonatal severe, neonatal mild, infantile mild, and infantile severe. Manish Prasad, “The Calm before the Storm”: Late Onset Glycine Encephalopathy Masquerading as Gastro-oesophageal Reflux

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Last date updated on September, 2024