EEG have been demonstrated a reliable diagnostic tool in dementia research . The increase of high alpha relative to low alpha power has been recently demonstrated a reliable EEG marker of hippocampal atrophy as well as conversion of patients with mild cognitive impairment (MCI) in Alzheimerââ¬â¢s disease. In the present study the association of EEG indexes with grey matter (GM) changes in NAc has been studied in subjects with MCI. The working hypothesis was that modifications of alpha3/alpha2 power ratio could be underpinned by different deep brain structures. Results show that subjects with higher a3/a2 ratios when compared to subjects with lower and middle a3/a2 ratios showed minor atrophy in the NAc bilaterally. VBM results were assessed at an uncorrected threshold of p < 0.001. This threshold has an important limit in that it allows the type I statistical error. Anyway, a more permissive threshold could be more adequate to this explorative study, it in order to avoid the beta (or type II) statistic error, with the risk to neglect interesting results. Anyway, the power of the study was allowed by size of the sample, and by the robust results of the subsequent analyses. VBM results were assessed at an uncorrectedthreshold of p < 0.001. This threshold has an important limit in that it allows the type I statistical error. Anyway, a more permissive threshold could be more adequate to this explorative study, it in order to avoid the beta (or type II) statistic error, with the risk to neglect interesting results. Anyway, the power of the study was allowed by size of the sample, and by the robust results of the subsequent analyses.
Moretti DV, Relationship between EEG Alpha3/Alpha2 Ratio and the Nucleus Accumbens in Subjects with Mild Cognitive Impairment
Last date updated on September, 2024
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