The significance of autoantibodies associated with neurological symptoms has been the focus of interest. Recent studies emphasized the pathogenic role of anti-gliadin antibody in gluten ataxia, an important disease of autoimmune cerebellar ataxia. To examine whether autoantibodies, including anti-gliadin antibody, play a pathogenic role, we analyzed the effects of CSF samples obtained from a Japanese patient with gluten ataxia on cerebellar synaptic transmission. The significance of autoantibodies associated with neurological diseases has been the focus of discussion. In most of autoimmune neurological disorders, it is not clear whether the antibody acts as a pathogenic agent causing symptoms, or it is produced as a result of cell-mediated autoimmune responses against neural structures. To confirm the pathogenic role of autoantibodies in the development of neurological symptoms. Autoimmune cerebellar ataxia is important since early diagnosis and therapy could relieve the symptoms, which is in contrast to spinocerebellar degeneration. The major two forms of the disease are gluten ataxia and GAD-Ab-associated ataxia.
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Last date updated on June, 2014