Mood disorders are expressed in many heterogeneous forms, varying from anxiety to severe
major clinical depression. The disorders are expressed in individual variety through manifestations governed by co-morbidities, symptom frequency, severity, and duration, and the effects of genes on phenotypes. The underlying etiologies of mood disorders consist of complex interactive operations of genetic and environmental factors. Among the mood disorders, adolescent depression is considered relatively common with prevalence ranging from 5% to about 14-15% in the United States of America and may predict adult
depression [Female sufferers from the disorder remain almost twice as many as male sufferers with the relative gender proportions evident already during adolescence. Additionally, gender differences in mood disorders are influenced by several personal and environmental factors, including physiological changes experienced during puberty, experienced-shift in social roles,
affiliations and expectations regarding peers and adults, and transient affective status that may provide negative/stressful experiences.
Blum K, Epigenetic Modulation of Mood Disorders
Last date updated on January, 2021