Medication therapy through improper injection techniques into a nerve may induce neuropathy, neuritis & injury. The aim is to analyse the pattern of this nerve lesion in clinical, pathological, and hematological parameters and also to study the outcome in a conservatively treated cohort. Damage to the sciatic nerve by injection has been reported from several parts of the world; these injuries are related mainly to a faulty injection technique and lack of trained man power capable of administering paranteral drugs in the developing countries .Injection injury account for 50% of sciatic nerve injuries in one large series reported from the USA. Medication therapy through improper injection techniques into a nerve may induce neuropathy, neuritis & injury. Iatrogenic nerve damage by injections may originate from needle puncture, the medication deposition, pressure from a hematoma or scarring around the nerve. Etiologies of sciatic neuropathy can include traumatic, compressive, ischemic, neoplastic, or idiopathic etiologies. Traumatic injuries can include injury to the sciatic nerve in association with femur fracture, hip dislocation or fracture, laceration, gunshot wound, or posterior thigh compartment syndrome. Sciatic neuropathy is second commonest mononeuropathy in the
lower limb after common peroneal nerve injury. The combination of trimethoprim and sulfamethoxazole secures a synergistic action against majority of gram positive and gram negative bacteria including penicillinase producing ones.
Farhang Sasani, Clinical, Pathological, and Hematological Study of Post-Injection Neuritis
of the Sciatic Nerve by Alfatrim 24% Intramuscular Injection in Small Ruminants
Last date updated on June, 2014