|Cachexia is defined as an extreme wasting condition with marked weight loss, anorexia, and lassitude. About half of all cancer patients show a syndrome of cachexia characterized by loss of adipose tissue and skeletal muscle mass. Such patients have a decreased survival time compared with that of patients without weight loss. Abnormal metabolism is thought to be the basis of the cachexia status in advanced cancer patients. Cachexia induces the cytokines, in particular tumor necrosis factor (TNF)-Î±, IL-1, and IL-6, is thought to inhibit the activity of lipoprotein lipase (LPL), and thereby induces weight loss as a result of reduced fat accumulation in the tissues. Therefore, it is thought that emaciation of cancer patients might be prevented and cachexia improved by increasing LPL activity
Review articles are the summary of current state of understanding on a particular research topic. They analyze or discuss research previously published by scientist and academicians rather than reporting novel research results.
Review article comes in the form of systematic reviews and literature reviews and are a form of secondary literature. Systematic reviews determine an objective list of criteria, and find all previously published original research papers that meet the criteria. They then compare the results presented in these papers. Literature reviews, by contrast, provide a summary of what the authors believe are the best and most relevant prior publications.
The concept of "review article" is separate from the concept of peer-reviewed literature. It is possible for a review to be peer-reviewed, and it is possible for a review to be non-peer-reviewed.