In this brief article, three topics, unrelated to each other, are emphasized;a mysterious mechanism of the earliest carcinoid formation, reevaluation
of original drawing of the submucosal nodule, and a consideration of terminology for this tumor. Grimelius- positive cells (G-cells) in a gastric gland derived from an
African rodent.On the left: the upper portion of the gland is entirely replaced by G-cells but the configuration of the gland is well preserved. The lower portion
is distorted with irregularly arranged G-cells apparently invading into the surroundings. Thus, one gland displays different stages of G-cell proliferation;
intraglandular preneoplastic - or frankly neoplastic-cell proliferation, and extraglandular (intramucosal) neoplastic-cell
proliferation with ââ¬Åbudding phenomenonââ¬Â. As a whole this gland discloses earliest carcinoid formation and its malignancy at its origin. On the right: one of multiple consecutive serial sections of the same
gland apart from the center exhibits somewhat blurred and distorted configuration of the gland in the upper portion but without definite
invasion, while obvious invasion to the surroundings is evident in the lower portion.
Last date updated on September, 2024