Hepatocellular carcinoma (HCC) is the most common primary liver neoplasm and the third leading cause of cancer deaths worldwide. Conventional therapies are not generally effective for advanced HCC and therefore a great effort is needed in developing approaches to prevent or reverse the progression of HCC. There is an emerging body of evidence that the peroxisome proliferator-activated nuclear receptors (PPAR) regulate the growth and proliferation of HCC cells. Herein, we provide a brief introduction to PPAR biology and review recent discoveries highlighting the importance of PPAR signalling in the modulation of hepatocellular carcinoma development and growth.
Emerging Role of the Peroxisome Proliferator-Activated Receptors in Hepatocellular Carcinoma (InÃ©s DÃaz-Laviada)
Last date updated on July, 2014