alexa Myocardial-infarction|OMICS International|Cardiovascular Pharmacology: Open Access

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Myocardial Infarction

Myocardial infarction ("heart attack") is the irreversible damage of myocardial tissue caused by prolonged ischemia and hypoxia. This most commonly occurs when a coronary artery becomes occluded following the rupture of an atherosclerotic plaque, which then leads to the formation of a blood clot (coronary thrombosis). This event can also trigger coronary vasospasm. If a vessel becomes completely occluded, the myocardium normally supplied by that vessel will become ischemic and hypoxic. Without sufficient oxygen, the tissue dies. The damaged tissue is initially comprised of a necrotic core surrounded by a marginal (or border) zone that can either recover normal function or become irreversibly damaged. The hypoxic tissue within the border zone may become a site for generating arrhythmias. Collateral blood flow is an important determinant of infarct size and whether or not the border zone becomes irreversibly damaged. Infarcted tissue does not contribute to tension generation during systole, and therefore can alter ventricular systolic and diastolic function and disrupt electrical activity within the heart. After several weeks, the infarcted tissue forms a fibrotic scar. Long-term consequences include ventricular remodeling of the remaining myocardium (e.g., development of compensatory hypertrophy or dilation), ventricular failure, arrhythmias and sudden death. Cardiovascular Relating to the circulatory system, which comprises the heart and blood vessels and carries nutrients and oxygen to the tissues of the body and removes carbon dioxide and other wastes from them. Cardiovascular diseases are conditions that affect the heart and blood vessels and include arteriosclerosis, coronary artery disease, heart valve disease, arrhythmia, heart failure, hypertension, orthostatic hypotension, shock, endocarditis, diseases of the aorta and its branches, disorders of the peripheral vascular system, and congenital heart disease. Cardiac therapy applications independently and as a profession have important positions to play in positively impacting medication policy, medication use and results as well as other aspects of medical proper care. In many instances this will be through cooperation with other wellness care professionals at a community stage. The following are the various actions that comprise the application of drug proper want to individuals. If performed, in whole or in part, they will result in added value to medication treatment by making a beneficial participation to the safe and affordable use of drugs, leading to beneficial results and improved medical proper care. Obtain and maintain medication records and relevant wellness details, if they do not already exist. This detail is essential to evaluate personalized medication treatment. Identify, evaluate and assess: Medication related problems, Symptoms described by patients, self-diagnosed conditions. The elements of drug proper take proper individual sufferers, taken together; explain comprehensive drug proper care, the delivery of which requires an ongoing, covenantal relationship between the pharmacologist and the affected person. The pharmacologist must use his clinical reasoning to determine the stage of drug proper care that is needed for each patient.
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Last date updated on May, 2014

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