The role of integrins and focal adhesions of the cells are significant in the adhesion and migration of the cells. Integrins are the most important receptors responsible for cellular adhesion processes with the extracellular matrix as well as with other cells. It is micro-meso structure of the scaffold provides an environment that is conducive to cell-scaffold adhesion. The mechanism of the integrin activity is through binding to a range of ligands on the cell surface and the extracellular matrix. This binding enables the receptors ability for signal transport between inside of the cell and outside.
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Last date updated on July, 2014