|The impact factor of journal provides quantitative assessment tool for grading, evaluating, sorting and comparing journals of similar kind. It reflects the average number of citations to recent articles published in science and social science journals in a particular year or period, and is frequently used as a proxy for the relative importance of a journal within its field. It is first devised by Eugene Garfield, the founder of the Institute for Scientific Information. The impact factor of a journal is evaluated by dividing the number of current year citations to the source items published in that journal during the previous two years.
Autophagy is the basic catabolic mechanism which involves mainly cell degradation of unnecessary or dysfunctional cellular components with the actions of lysosomes. The breakdown of cellular components can ensure cellular survival during starvation by maintaining their cellular energy levels. If Autophagy regulated, ensures the synthesis, degradation and recycling of the cellular components. During this autophagy process, targeted cytoplasmic constituents are isolated from the rest of the cell within the autophagosomes, which fuses with lysosomes and recycled or degraded. There are three different kinds of autophagy that are commonly described; microautophagy ,macroautophagy, and chaperone-mediated autophagy. With the context of disease, autophagy has been observed as an adaptive response to survival, whereas in other cases it appears to promote cell death and morbidity. There are three main pathways involved in autophagy and these are mediated by the autophagy-related genes and their associated enzymes. Macroautophagy is the main pathway, occurring mainly to eradicate the damaged cell organelles or unused proteins which involve the formation of a double membrane around cytoplasmic substrates resulting in the organelle known as an autophagosome. Microautophagy, on the other hand, involves the direct engulfment of cytoplasmic material into the lysosome which occurs by invagination i.e the inward folding of the lysosomal membrane, or cellular protrusion. Chaperone-mediated Autophagy is a very complex and specific pathway, involving the recognition by the hsc70-containing complex.