Peer review refers to the work done during the screening of submitted manuscripts and funding applications. This process encourages authors to meet the accepted standards of their discipline and reduces the dissemination of irrelevant findings, unwarranted claims, unacceptable interpretations, and personal views. Publications that have not undergone peer review are likely to be regarded with suspicion by academic scholars and professionals.
Cells are the rudimentary construction blocks of tissues. All cells experience changes with aging. They become bigger and are less adept to split up and reproduce. Amidst other alterations, there is an increase in pigments and fatty substances interior the cell (lipids). Many cells lose their ability to function, or they start to function abnormally. Senescence or biological aging is the process of accumulative alterations to molecular and cellular structure that disturbs metabolism with the passage of time, producing in deterioration and death. Cellular aging is the phenomenon by which normal diploid cells cease to split up, commonly after about 50 cell partitions in vitro. Cellular aging is causally implicated in generating age-related phenotypes, and removal of senescent units can avert or hold up tissue dysfunction and continue healthspan. The method of aging is complex, and may derive from a kind of different mechanisms and live for a kind of distinct causes. However, aging is not universal, and technical clues propose that cellular aging developed in certain species because it prevents the onset of cancer. The function of telomeres in cellular aging has aroused general interest, especially with a outlook to the possible genetically adverse consequences of cloning. In about 85% of tumors, this evasion of cellular senescence is the result of up-activation of their telomerase genes.
Last date updated on September, 2014