|Scholarly journal is a peer-reviewed journal in which scholarship relating to a particular academic discipline is published. Scholarly journals serve as forums for the introduction and presentation for scrutiny of new research, and the critique of existing research. Content typically takes the form of articles presenting original research, review articles, and book reviews. The term Scholarly journal applies to scholarly publications in all fields; this article discusses the aspects common to all academic field journals.
Circulating Tumor Cells (CTCs), shed into the bloodstream from primary and metastatic tumors are regarded as the liquid biopsy of cancer is an enthusiastic field of research which attracted half-a thousand publications in the recent two decades. The Circulating Tumor Cells research can be categorized into three major aspects: 1) Clinically focused on the applications of Circulating Tumor Cells as biomarkers for cancer diagnosis, progression, prognosis and therapeutics; 2) Molecular characterization of Circulating Tumor Cells to determine their clinical relevance and functional activities in tumor microenvironments; and 3) Technological investment in detection and isolation of rare Circulating Tumor Cells from peripheral blood specimens and even in vivo tracking of Circulating Tumor Cells. High Circulating Tumor Cells numbers have been correlated with increased metastasis and decreased time to relapse, which supporting the predictive values on cancer progression, prognosis and survival in several cancers. A meta-analysis of 49 eligible studies enrolling 6,825 breast cancer patients indicated Circulating Tumor Cells a stable prognostic biomarker at both earlyand metastatic stages. Such encouraging reports have directed many investigators into the search of various strategies in Circulating Tumor Cells enrichment to achieve the limit of detection at one Circulating Tumor Cells per million cells level.(John YWM, Mayur-Danny GI, Circulating Tumor Cells â Cutting Edge Research?)