|Gene Technology is one of the leading Scholarly journals in Modern Biotechnology. The journal strives to add in theoretical and technological innovations as part of its publishing remit and is devoted to publishing the highest quality papers. The administration of the journal is integrative, reflecting the fact that imaging neuroscience is a multi-disciplinary science.
The eukaryotic chromosome is linear, with a centromere and telomere. The chromosome replicates from the origin of replication during the S-phase of the cell cycle. The centromere proteins, CENP-A,-B, and -C, located in the centromere sequence, assist with assembly of the kinetochore complex during the M phase. Then, the spindle fiber is attached to the kinetochore, and the chromosome is distributed to both poles. In this way, replicating chromosomes are distributed to daughter cells, and the genomic information of a mother cell is stably transmitted to daughter cells. Physiologically, the same mechanisms are used for the replication and distribution of HAC vectors. "Mitsuo Oshimura, Toward Gene and Cell Therapies Employing Human Artificial Chromosomes in Conjunction with Stem Cells"
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