Chronic Alcoholism

Chronic ethyl alcohol consumption damages almost all organs and tissues. Such effects are secondary to direct toxicity of alcohol and metabolites, while it is also known that intestinal absorption of folate and Vitamin B12 is impaired. In addition, it is found that free radicals play a role in tissue damage secondary to metabolism of alcohol. Whatsoever the mechanism, chronic alcoholism results with many hepatic conditions ranging from fatty degeneration to cirrhosis, acute or chronic pancreatitis, alcoholic cardiomyopathy, and neurological lesions ranging from WernieckeKorsak of syndrome, peripheral neuropathy and cerebral and cerebellar atrophy, and gastritis, peptic ulcer and endocrine disorders such as testicular atrophy and amenorrhea. Alcoholic liver disease is a clinical picture which is characterized with excess consumption of alcohol for long term and variable hepatic injury. Alcoholic liver disease is a condition which is due to cumulative alcohol intake for a long period of time and characterized by hepatic injury with a variable severity. Excess consumption of alcohol leads to Alcoholic Liver Disease [ALD] which is associated with excess iron accumulation and is characterized with hepatosteatosis, fibrosis, hepatitis and cirrhosis.

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Last date updated on April, 2024