Programmed cell death or apoptosis is one of the major contributors to the development of a normal immune system, the developmentally correct architecture of tissues and organs and the proper maintenance of organ homeostasis. However, dysfunctional induction of apoptosis appears to be critical for the aberrant survival of pathological cells imany chronic immune-mediated disorders, inflammation and cancer. Being one of the major and relevant immune reaction that has key role in most of the immune diseases, journal of clinical and cellular immunology has released a special issue on this topic Immune Response and Apoptosis.
âThis Special Issue of the Journal of Clinical and Cellular Immunology devoted to Immune Response and Apoptosis reviews the recent advances in our understanding of how the balance between cell survival and apoptosis is regulated and maintained in the normal state including the role apoptosis plays in regulating T-lymphocyte development, how apoptosis acts as a fundamental cellular process responsible for suppressing the activity of antigen-presenting dendritic cells (DCs) a key step in controlling immune tolerance, and how apoptosis acts as the critical modulator of innate and adaptive immunity.
Last date updated on July, 2014