|Innate immunity is the inborn immunity of the person. Innate immunity is non-specific in nature. The response of innate immune depends on the recognition of evolutionarily conserved structures present on pathogens, called pathogen-associated molecular patterns (PAMPs). The innate immune system is based mainly on physical and chemical barriers. There are three components of the innate immune system that includes anatomical barrier, humoral barrier and cellular barrier. Anatomical barriers called first line of defense includes skin, saliva, tears, mucus and cilia present in intestinal and respiratory tract. Skin act as a mechanical barrier whereas others are chemical barriers. If the pathogen escapes anatomical barriers acute inflammation occurs and humoral barrier comes into play. Humoral barriers include complement system and interleukin. Last is the cellular barrier that destroys the pathogen if it has entered the body by crossing the first two barriers. It includes various cells like neutrophils, macrophages, natural killer cells and dendritic cells.
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