Signal transduction is an internal communication process that mediates cells metabolism, gene expression, cell proliferation and other related mechanisms. This process of signal transduction mediates regulation of various cellular processes including regulation of immune cells and related mechanisms. Cell signaling is of two types: They are intra cellular signaling and extracellular signaling. This process is plays a central role in most of the cellular mechanisms.
The process of signaling is the major mechanism of activation of various immune cells. The interaction of different ligands with receptors will trigger the cells to fight with the invading pathogens. Immune signaling mediated several processes such as activation of inflammatory mechanisms, antigen binding, secretion of immune mediators, chemotaxis etc.
Since being an important topic in cellular immunology, JCCI has released a special issue on âSignal Transduction Mechanisms in T lymphocytes edited by Dr. Noah Isakov from Ben Gurion University of the Negev. The special issue was compiled with interesting articles based on various aspects of signal transduction and its role in t-lymphocyte maturation.
Last date updated on July, 2014