Distribution in pharmacology is a branch of pharmacokinetics which describes the reversible transfer of drug from one location to another within the body.The organ or tissue receives different quantity of drug doses and the drug is remained in the different organs or tissues for a variable amount of time. The distribution of a drug doses between tissues is reliant on vascular permeability, cardiac output, regional blood flow and perfusion rate of the tissue and the binding of drug to tissue and plasma proteins and its lipid solubility. pH partition also takes part in drug distribution. In highly perfused organs such as the liver, heart and kidney Drugs can be easily distributed. At perfused tissues like muscle, fat and peripheral organs drugs is distributed in small quantity. when the equilibrium is known the unbound drug present in plasma is distributed from the plasma to the tissue. Factors Affecting Drug Distribution: Particle size of the drugs, Proteins Binding, Surface area of the Drug, Excretion, pH, Temperature, Physical Volume of the Body Etc.
The impact factor of journal provides quantitative assessment tool for grading, evaluating, sorting and comparing journals of similar kind. It reflects the average number of citations to recent articles published in science and social science journals in a particular year or period, and is frequently used as a proxy for the relative importance of a journal within its field. It is first devised by Eugene Garfield, the founder of the Institute for Scientific Information. The impact factor of a journal is evaluated by dividing the number of current year citations to the source items published in that journal during the previous two years.
Last date updated on July, 2014