In pharmacology the elimination or excretion of a drug is a process by which a drug is eliminated from the body either in an unaltered form, unbound molecules or modified as a metabolite. These organs use a particular system to remove a drug from the body, these are known as elimination pathways: Urine, Tears, Milk, Respiration, Perspiration, Saliva, Faeces, Bile. Glomerular filtration is a major process that involves in the excretion of drug and by active tubular secretion followed the same process and mechanisms as the products of intermediate metabolism. Therefore, drugs that involved in the glomerulus filtration are also subject to the process of passive tubular reabsorption. Drugs or metabolites that are not bound to proteins present in blood plasma and many other types of drugs (such as the organic acids) are actively excreted by Glomerular filtration. In the proximal and distal convoluted tubules non-ionised acids and weak bases are reabsorbed both actively and passively. When the tubular fluid becomes too alkaline,weak acids are excreted and this reduces passive reabsorption. The opposite occurs with weak bases.
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Last date updated on July, 2020