Cell & gene therapy technologies are ruling the world of therapeutic area due to high accuracy in the treating and with fewer disadvantages, and also promising alternative for diseases that so far have no effective treatment. Nanotechnology ("nanotech") is the manipulation of matter on an atomic, molecular, and supramolecular scale. Even through the treatment seems to be simple it involves a high sophisticated technology and equipment. To over cum the small stumbling blocks in this the field gene therapy joined the hands with nanotechnology this facilitate the genes and drugs to the tip of action so that they can produce the desired effect. The team working on this shown that lipid nanoparticles, are ideal for acting as vectors in gene therapy. It consists of delivering a nucleic acid, for example, a therapeutic gene, to amend the expression of a protein that is found to be transformed in a particular disease, thus reversing the biological disorder.
The main obstruction is that the genetic materials are highly sensitive cannot be formulated in traditional pharmaceutical ways, because it becomes degraded within the organism and cannot perform its function and leads to lethality, to overcome viral vectors are generally employed to deliver the therapeutic gene to the cells in which it has to act and desired protein is expressed. Sometimes these viral vectors may revert and also leads to tumours hence researchers are preferring non viral vectors which doesnt show biological alterations and also poses ideal characters of therapeutic gene transfer. This made to evolve lipid nano particles which carry desired gene with its own biological way.
Lipid Nanoparticles have been successfully applied in treating ocular degeneration where ocular delivery of therapeutic gene has been done. Another supreme application of this technology is in formulation of drugs which are not soluble or which are much difficult to absorb into in to the body by natural means. The researchers are trying to increase effectiveness of this technology by all means combining these three skills Pharmacokinetics, Nanotechnology and Gene Therapy.
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Last date updated on November, 2020