|Cytotoxicity is the quality of being toxic to cells. Examples of toxic agents are an immune cell or some types of venom, e.g. from the puff adder (Bitis arietans) or brown recluse spider (Loxosceles reclusa). The cytotoxic compounds affects the cells by causing uncontrolled cell death, prevents cell growth and cell division. The exposure of cytotoxic compounds to the cells causes the cells to undergo necrosis by nuclear and cytoplamic condensation and loss of memberane integrity. The ability of cytotoxic compounds to prevent the cell division can be utilized to prevent the uncontrolled proliferation of cancer cells. This property of cytotoxic compounds is a recent breakthrough in the field of anticancer drug discovery. In most of the drug discovery procedures, Cytotoxicity of the drug is tested to ensure that the drugs may not cause Cytotoxicity.
The impact factor of journal provides quantitative assessment tool for grading, evaluating, sorting and comparing journals of similar kind. It reflects the average number of citations to recent articles published in science and social science journals in a particular year or period, and is frequently used as a proxy for the relative importance of a journal within its field. It is first devised by Eugene Garfield, the founder of the Institute for Scientific Information. The impact factor of a journal is evaluated by dividing the number of current year citations to the source items published in that journal during the previous two years.