Biopharmaceuticals are the chemical entities that are used as medical drugs in the treatment of illness which are produced by using biotechnological techniques. The biopharmaceuticals basically includes the macro-molecular products like proteins, nucleic acids, etc. which are employed as protein-based (like antibodies) and or nucleic acid-based (like antisense-oligonucleotide) drugs. The microorganisms like viruses and bacteria can also be used as biopharmaceutical therapeutics and or finds its application as in vivo diagnostic purposes. This subset of biopharmaceuticals including attenuated microorganisms and or the medical products composed of cellular or tissue based matter is generally referred as biologics for example stored RBC units. The attenuated microorganisms whose virulence has been reduced are produced by means other than the direct extraction from their native biological sources as using non-engineered biological sources may pose the higher risks in its usage. The first biopharmaceutical substance produced and approved for therapeutic use was insulin via recombinant DNA technology. The top open access journals are peer reviewed scholarly journals of Clinical & Experimental Pharmacology. The top open access journals are freely available on the public internet domain, allowing any end users to read, download, copy, distribute, prink, search or link to the full texts of the articles. These provide high quality, meticulously reviewed and rapid publication, to cater the insistent need of scientific community.These journals are indexed with all their citations noted. The top open access journals are indexed in MEDLINE, PUBMED, SCOPUS, COPERNICUS, CAS, EBSCO and ISI.
Last date updated on June, 2014