Cytotoxicity is the quality of being toxic to cells. Examples of toxic agents are an immune cell or some types of venom, e.g. from the puff adder (Bitis arietans) or brown recluse spider (Loxosceles reclusa). Cytotoxic compounds mainly cause carcinogenic, mutagenic and teratogenic affects on exposure. The cytotoxic compounds affects the cells by causing uncontrolled cell death, prevents cell growth and cell division. The exposure of cytotoxic compounds to the cells causes the cells to undergo necrosis by nuclear and cytoplamic condensation and loss of memberane integrity. The ability of cytotoxic compounds to prevent the cell division can be utilized to prevent the uncontrolled proliferation of cancer cells. This property of cytotoxic compounds is a recent breakthrough in the field of anticancer drug discovery. In most of the drug discovery procedures, Cytotoxicity of the drug is tested to ensure that the drugs may not cause Cytotoxicity.
The top open access journals are freely available on the public internet domain, allowing any end users to read, download, copy, distribute, prink, search or link to the full texts of the articles. These provide high quality, meticulously reviewed and rapid publication, to cater the insistent need of scientific community. These journals are indexed with all their citations noted. The top open access journals are indexed in MEDLINE, PUBMED, SCOPUS, COPERNICUS, CAS, EBSCO and ISI.
Last date updated on September, 2014