Clinical toxicology evaluates the toxic effects of chemicals, drugs, environmental pollutants, and many other agents which are able to alter the human body physiology, after the initial phases of investigation, the toxic effects are later focused at the cellular levels starting from the morphology and biochemistry to the gene level. However, like other physiological events, only genetic analysis is not sufficient to understand the mechanisms of toxicity of chemicals in human body. Toxic agents could act at different levels by directly modifying both the genome and epigenome or indirectly by altering
signaling pathways. These alterations in chromatin structure may or may not be heritable but probably are reversible. Currently, there are insufficient data to support inclusion of epigenetic profiling into
pre-clinical evaluation studies. Many International collaborative efforts are necessary to generate data to determine whether epigenetic modifications have any link in health and diseases The Time has Come for Clinical Toxicologists to Enter into the Post-Genomic Era, Asok Dasmahapatra.
Thus the field of toxicology is finding its new phase of growth towards toxicogenomics where the future of toxicology lies. Our journal of clinical toxicology is also thus finding its own way space in supporting this upcoming research through our review articles, editorials and short communications.
Last date updated on June, 2014