Brugada Syndrome

Patients with Brugada syndrome have mutations in the gene encoding cardiac sodium channels and this disease is the major cause of ventricular tachyarrhtmia in young patients. In these patients SDNN and LF power of beating interval are reduced. A lack of sympathetic drive in the presence of sustained parasympathetic, drive together with a reduction in cAMP level (due to a direct feedback from a reduction in Na that decreases the Ca2+ balance in the cell), were documented in patients with Brugada syndrome.

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Last date updated on July, 2025