Carcinogenesis is a very complex process that involves dynamically inter-connected biomolecules in the intercellular, membrane, cytosolic, nuclear and nucleolar compartments that form numerous inter-related pathways referred to as networks. One such family of signaling pathways contains the cell cyclins. Cyclins are often over-expressed in cancerous cells . This provides a basis for the development of novel rational chemotherapies and chemoprevention of cancers. The analysis of cancer models including CDKs and signaling pathways suggests the possibility of optimizing novel clinical trials through the development of rational therapies of cancer and the possibility of reestablishing cell cycling inhibition in metastatic cancer cells without subsequent transformations that lead to drug resistance.
Last date updated on July, 2014