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Medullary Carcinomas

Medullary carcinomas are genetically different from conventional ductal carcinomas of the pancreas. Three out of five medullary carcinomas described by Goggins et al. showed both Microsatellite Instability (MSI) and a wild type K- ras gene. These results are not typical for conventional ductal adenocarcinomas which almost always harbor K-ras gene mutations and seldom if ever have MSI. Further investigations with a larger series of medullary carcinomas have elucidated clinical and genetic features associated with medullary morphology