"Circulating complement products indicate the complement system is activated but surface receptors are saturated causing the factors to accumulate in plasma. Complement activation by the complement component 3 (C3) and complement component 5a (C5a) fragments are associated with pregnancy loss showing complement activation can adversely affect pregnancy. C8 and C9 are activated in the final steps to form pores on target cells and induce cell death by contributing to the membrane attack complex (MAC). Complement component 8 (C8) andcomplement component (C9) were observed as ambiguously regulated in two studies, one serum source reported C8 and C9 as down regulated t delivery.
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Citation: Wong F, Cox B (2014) Proteomics Analysis of Preeclampsia, a systematic Review of Maternal and Fetal Compartments. J Proteomics BioinformS10: 001."
Last date updated on July, 2014