4 / 41
Page 48
Notes:
conferenceseries
.com
Volume 5, Issue 5 (Suppl)
Nat Prod Chem Res
ISSN: 2329-6836 NPCR, an open access journal
Pharmacognosy 2017
July 24-25, 2017
July 24-25, 2017 Melbourne, Australia
5
th
International Conference and Exhibition on
Pharmacognosy, Phytochemistry
& Natural Products
An efficient synthesis of a bioactive benzenoid derivative from the mycelium of
Antrodia camphorate
and
its anti-viral activity
Shu-Han Yang
1,2
, Jyuan-Siou Lin
1,3
, Shu-Hao Lee
1
, Chang-Jer Wu
3
and Ching-Kuo Lee
2
1
Power Nature Company, Taiwan
2
Taipei Medical University, Taiwan
3
National Taiwan Ocean University, Taiwan
A
ntrodia Camphorata
(AC), a highly valued polypore mushroom native only to Taiwan, has been traditionally used as a medicine
for the treatment of liver-related cancer and inflammation syndromes. Compound S3 was isolated from the mycelium of AC.
In this study we found that S3 displayed potent anti-influenza A virus activity. Influenza A (H
1
N
1
) virus is the subtype of influenza A
virus that was the most common cause of human influenza (flu) in 2009. Now the influenza A (H
1
N
1
) treatment is done by Tamiflu®.
However, Tamiflu® has a lot of side effects, for example users may have mental illness symptoms. The cytotoxicity evaluation of S3
against baby hamster kidney cell lines (BHK-21) showed that S3 was slightly higher active than Tamiflu® (cell viability still has more
than 80%), but S3 treatment effect better than Tamiflu®. In addition, the animals have no adverse effects after long-term use S3. It was
a potent inhibitor of influenza A (H
1
N
1
) virus, with higher activity than the reference compound Tamiflu®. However, the content of
S3 is rarely found in the mycelium of AC. Synthesia of the key chemical S3 compound in our laboratory was done through the AlC
l3
followed by demethylation. The yield was 23% in one step. This paper offers the first report of the anti-influenza A virus activity by
S3. Moreover the key benzenoid component S3 was prepared only in one step.
Biography
Shu-Han Yang has completed her Master’s degree from National Taiwan Normal University. She is an Assistant Researcher at Research and Development
Department of Power Nature Company and School of Pharmacy of Taipei Medical University. She has published 1 paper in reputed journal.
a78322003@hotmail.comShu-Han Yang et al., Nat Prod Chem Res 2017, 5:5 (Suppl)
DOI: 10.4172/2329-6836-C1-017