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Volume 5, Issue 5 (Suppl)

Nat Prod Chem Res

ISSN: 2329-6836 NPCR, an open access journal

Pharmacognosy 2017

July 24-25, 2017

July 24-25, 2017 Melbourne, Australia

International Conference and Exhibition on

Pharmacognosy, Phytochemistry

& Natural Products

Chemical constituents from the red alga-derived fungus

Acremonium

sp. NTU492

Chia-Yu Chen

National Taiwan University, Taiwan

arine natural products were the secondary metabolites of marine organisms with highly diversified structural features and

varied bioactivities that keep the chemists and pharmacologists being intrigued. Among the great diversified species in

the ocean, endophytic fungi remained to be less investigated so far. It was shown that marine-derived fungi were a rich source of

structurally unique chemical entities. Thus, a number of endophytic fungal strains were isolated from marine algae collected from

north eastern coast of Taiwan. In the preliminary antimicrobial screening against bacteria and fungi, including

Escherichia coli,

Staphylococcus aureus, Candida albicans

and

Cryptococcus neoformans

, the ethyl acetate extracts of liquid (potato dextrose broth) and

solid (brown rice) fermented products of

Acremonium

sp. NTU492, a derived fungus from the red alga

Mastophora rosea

, were found

to exhibit significant growth inhibitory activity against

C. albicans

and

C. neoformans

. A series of bioassay-guided fractionation and

separation was thus undertaken, and which has resulted in the isolation and purification of six peptides along with a trichothecene.

Of these, new compounds were determined to be one depsipeptide and three highly N-methylated linear peptides, respectively, by

spectral data and in comparison with literatures.

Biography

Chia-Yu Chen has obtained her Bachelor’s degree from the Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan. She is

presently studying in the Aquatic Microbial Metabolomics Laboratory in the Institute of Fisheries Science, National Taiwan University, Taipei, Taiwan.

r05b45004@ntu.edu.tw

Chia-Yu Chen, Nat Prod Chem Res 2017, 5:5 (Suppl)

DOI: 10.4172/2329-6836-C1-017