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conferenceseries
.com
Volume 5, Issue 5 (Suppl)
Nat Prod Chem Res
ISSN: 2329-6836 NPCR, an open access journal
Pharmacognosy 2017
July 24-25, 2017
July 24-25, 2017 Melbourne, Australia
5
th
International Conference and Exhibition on
Pharmacognosy, Phytochemistry
& Natural Products
Effects of active compounds from
Turpinia formosana
on osteoblast cells
Mei-Hsien Lee, Yi-Fiang Wang and Zuha Imtiyaz
Taipei Medical University, Taiwan
T
urpinia formosana
belongs to Staphyleaceae family; it is endemic to Taiwan and is found in the hilly areas. The plant is a small
evergreen shrub. The following study starts with the extraction, which was done by using 95% ethanol from the leaves of the plant
and later the fractionation was done using various solvents n-hexane, ethyl acetate (EtOAc) and n-butanol (n-BuOH). The isolated
compounds were identified by using different physical and spectroscopic properties. Six compounds including one new ellagic acid
derivative from EtOAc layer and five known compounds classified as hydrolysable tannins from n-BuOH layer were obtained. Effects
of isolated compounds were determined on the human osteoblast (HOb) cells and the compounds giving the viability more than 80%
were taken into positive consideration. Further, ALP activity and mineralization ability of the CP-1 (new compound) and CP-2 was
evaluated in order to elucidate their effect and efficacy on HOb cells. And we observed that the new compound which is an ellagic
acid derivative (CP-1) showed more ALP activity as well as mineralization which was found to be 119.58% and 128.99%, respectively.
Because of all these properties which prove to be more promising in CP-1, it seems that CP-1 can be the potential therapeutic target
for further research and can prove to be another milestone in the treatment of osteoporosis.
Biography
Mei-Hsien Lee is a Professor in Graduate Institute of Pharmacognosy in Taipei Medical University, Taiwan. Her research interest are Chinese herbal medicine
Translational Research, Pharmacognosy, Chinese herbal medicine, Chinese medicine chemical, Active natural products chemistry, Functional cosmetic raw
materials and active R & D. She was appreciated by various awards.
lmh@tmu.edu.twMei-Hsien Lee et al., Nat Prod Chem Res 2017, 5:5 (Suppl)
DOI: 10.4172/2329-6836-C1-017