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Volume 5, Issue 5 (Suppl) Nat Prod Chem Res
ISSN: 2329-6836 NPCR, an open access journal Pharmacognosy 2017
July 24-25, 2017
July 24-25, 2017 Melbourne, Australia
5th International Conference and Exhibition on
Pharmacognosy, Phytochemistry
& Natural Products
Dehydroandrographolide inhibits human oral cancer metastasis by transcriptionally repressing MMP-2
Shun-Fa Yang and Ming-Ju Hsieh
Chung Shan Medical University, Taiwan
Oral cancer is one of the most common cancers worldwide and metastasis is recognized as a major factor causing its low
survival rate. It is a critical research objective to inhibit the metastasis progress and improve the survival rate for oral cancer.
Dehydroandrographolide is the principal component of Andrographis paniculata (Burm.f.) Nees and is the main contributors to its
therapeutic properties. However, the molecular mechanism underlying the anticancer effect induced by dehydroandrographolide
remainsunclear.Inthisstudy,weinvestigatedtheeffectofdehydroandrographolideonSCC-9oralcancercellsandexaminedthepotential
inhibitory mechanisms involved. The results indicated that dehydroandrographolide attenuated the migration and invasion abilities
of SCC-9 cells by reducing the activity and protein expression of matrix metalloproteinases-2 (MMP-2). Dehydroandrographolide
inhibited the phosphorylation of ERK1/2, p38 and JNK 1/2 in SCC-9 cells. According to the mRNA levels detected using real-time
PCR, dehydroandrographolide inhibited MMP-2 expression in SCC-9 cells. In addition, dehydroandrographolide administration
effectively suppressed MMP-2 expression and tumor metastases in the oral carcinoma xenograft mouse model in vivo. These data
indicate that dehydroandrographolide could be a potent therapeutic agent for the prevention and treatment of oral cancer and a
prominent plant source for anticancer research in the future.
Biography
Shun-Fa Yang is a Professor of Institute of Medicine, Chung Shan Medical University, Taiwan. He has received his PhD degree in Molecular Biology. In particular,
his researches have been focused on pharmacology, head and neck cancer metastasis, cancer biology, genetic polymorphism and environment risk factors in
cancer.
Shun-Fa Yang et al., Nat Prod Chem Res 2017, 5:5 (Suppl)
DOI: 10.4172/2329-6836-C1-017