|Type 2 diabetes (T2DM) is characterized by insulin resistance and beta cell dysfunction. Beta cell dysfunction is a core factor in the pathogenesis of T2DM. Deficit of beta cell mass in humans with T2DM has also been reported, probably through an increase in beta cell apoptosis. Beta cell dysfunction is not only present in T2DM but also progressively worsens with duration of the disease. Beta cell function starts to decline even within the normal range of glucose tolerance. Higher plasma insulin simply reflects greater insulin demand due to decreased insulin sensitivity. Thus, true beta cell function needs to be assessed with adjustment for concomitant insulin sensitivity. Beta cell mass in patients with T2DM is hyperplastic or at least normal. More importantly, the decline of beta cell function with higher glucose level appears to be similar in lean and obese subjects, suggesting that the significance of beta cell function in the development of glucose intolerance is independent of the presence of obesity.
Journal of Diabetes & Metabolism publishes research on prevention, pharmacological treatment, management, and education of diabetes and related disorders. OMICS Group under an Open Access category projects a comparatively new model for scholarly journal publishing that provides straight away, worldwide, barrier-free access to the full-text of all published articles.
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